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KMID : 0390020120220020171
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Pediatric Allergy and Respiratory Disease
2012 Volume.22 No. 2 p.171 ~ p.179
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Usefulness of FEV Δ 0.75 and FEV Δ 0.5 for Airway Reversibility in Preschoolers with Asthma
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Park Hyun-Bin
Kim Yoon-Hee
Baek Ji-Young
Kim Kyung-Won
Sohn Myung-Hyun
Kim Kyu-Earn
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Abstract
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Purpose: Preschoolers complete forced expiration in a short time, sometimes more quickly than in 1 second, and therefore the importance of forced expiatory volume in 0.75 seconds (FEV0.75) or forced expiatory volume in 0.5 seconds (FEV0.5) has been raised. The purpose of this study is to evaluate the clinical usefulness of ΔFEV0.75 and ΔFEV0.5.
Methods: We analyzed 401 subjects of an asthma group, and 150 subjects of a control group under 7 years of age.
Results: ΔFEV1, ΔFEV0.75 and ΔFEV0.5 values of the asthma group were significantly higher than those of the control group, respectively (P <0.0001). ΔFEV1 (0.60; 95% confidence interval [CI], 0.57 to 0.62), ΔFEV0.75 (0.61; 0.58 to 0.65), and ΔFEV0.5 (0.60; 0.56 to 0.64) showed no significant difference in the diagnostic ability of asthma when airway reversibility is defined as ΔFEVt≥12%. Cutoff values for asthma were 8.6% in ΔFEV1, 7.9% in ΔFEV0.75 and 14.2% in ΔFEV0.5. ΔFEV0.75 (0.91; 0.88 to 0.94) showed significantly higher area under curve (AUC) than ΔFEV0.5 (0.77; 0.73 to 0.82) when stratified by 12%, in predicting airway reversibility defined as ΔFEV1≥12%. Cutoff values were 12.3% in ΔFEV0.75, and 13.4% in ΔFEV0.5. When airway reversibility is defined as ΔFEV1 ≥8.6%, ΔFEV0.75 (0.90; 0.87 to 0.92) also showed significantly higher AUC than ΔFEV0.5 (0.79; 0.75 to 0.82), and Cutoff values were 8.4% in ΔFEV0.75, and 11.3% in ΔFEV0.5.
Conclusion: ΔFEV0.75 or ΔFEV0.5 can be a means to replace ΔFEV1 for diagnosis of asthma and assessment of airway reversibility in preschool children.
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KEYWORD
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Spirometry, Preschool children, Asthma, Forced expiratory volume
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